The anti-estrogen receptor drug, tamoxifen, is selectively Lethal to P-glycoprotein-expressing Multidrug resistant tumor cells

BACKGROUND: P-glycoprotein (P-gp), a member of the ATP Binding Cassette B1 subfamily (ABCB1), confers resistance to clinically relevant anticancer drugs and targeted chemotherapeutics. However, paradoxically P-glycoprotein overexpressing drug resistant cells are “collaterally sensitive” to non-toxic...

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Detalles Bibliográficos
Autores principales: Bakadlag, Rowa, Limniatis, Georgia, Georges, Gabriel, Georges, Elias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824978/
https://www.ncbi.nlm.nih.gov/pubmed/36609245
http://dx.doi.org/10.1186/s12885-022-10474-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824978/
https://www.ncbi.nlm.nih.gov/pubmed/36609245
http://dx.doi.org/10.1186/s12885-022-10474-x

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