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The anti-estrogen receptor drug, tamoxifen, is selectively Lethal to P-glycoprotein-expressing Multidrug resistant tumor cells

BACKGROUND: P-glycoprotein (P-gp), a member of the ATP Binding Cassette B1 subfamily (ABCB1), confers resistance to clinically relevant anticancer drugs and targeted chemotherapeutics. However, paradoxically P-glycoprotein overexpressing drug resistant cells are “collaterally sensitive” to non-toxic...

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Detalles Bibliográficos
Autores principales:	Bakadlag, Rowa, Limniatis, Georgia, Georges, Gabriel, Georges, Elias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824978/ https://www.ncbi.nlm.nih.gov/pubmed/36609245 http://dx.doi.org/10.1186/s12885-022-10474-x

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