Computationally-guided design and selection of high performing ribosomal active site mutants

Understanding how modifications to the ribosome affect function has implications for studying ribosome biogenesis, building minimal cells, and repurposing ribosomes for synthetic biology. However, efforts to design sequence-modified ribosomes have been limited because point mutations in the ribosoma...

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Detalles Bibliográficos
Autores principales: Kofman, Camila, Watkins, Andrew M, Kim, Do Soon, Willi, Jessica A, Wooldredge, Alexandra C, Karim, Ashty S, Das, Rhiju, Jewett, Michael C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825160/
https://www.ncbi.nlm.nih.gov/pubmed/36484094
http://dx.doi.org/10.1093/nar/gkac1036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825160/
https://www.ncbi.nlm.nih.gov/pubmed/36484094
http://dx.doi.org/10.1093/nar/gkac1036

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