Genome-scale top-down strategy to generate viable genome-reduced phages

Efforts have been made to reduce the genomes of living cells, but phage genome reduction remains challenging. It is of great interest to investigate whether genome reduction can make phages obtain new infectious properties. We developed a CRISPR/Cas9-based iterative phage genome reduction (CiPGr) ap...

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Detalles Bibliográficos
Autores principales: Yuan, Shengjian, Shi, Juan, Jiang, Jianrong, Ma, Yingfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825161/
https://www.ncbi.nlm.nih.gov/pubmed/36511873
http://dx.doi.org/10.1093/nar/gkac1168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825161/
https://www.ncbi.nlm.nih.gov/pubmed/36511873
http://dx.doi.org/10.1093/nar/gkac1168

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