Monitoring drug–target interactions through target engagement-mediated amplification on arrays and in situ

Drugs are designed to bind their target proteins in physiologically relevant tissues and organs to modulate biological functions and elicit desirable clinical outcomes. Information about target engagement at cellular and subcellular resolution is therefore critical for guiding compound optimization...

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Detalles Bibliográficos
Autores principales: Al-Amin, Rasel A, Johansson, Lars, Abdurakhmanov, Eldar, Landegren, Nils, Löf, Liza, Arngården, Linda, Blokzijl, Andries, Svensson, Richard, Hammond, Maria, Lönn, Peter, Haybaeck, Johannes, Kamali-Moghaddam, Masood, Jensen, Annika Jenmalm, Danielson, U Helena, Artursson, Per, Lundbäck, Thomas, Landegren, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825164/
https://www.ncbi.nlm.nih.gov/pubmed/36189884
http://dx.doi.org/10.1093/nar/gkac842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825164/
https://www.ncbi.nlm.nih.gov/pubmed/36189884
http://dx.doi.org/10.1093/nar/gkac842

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