Thiopurines impair the apical plasma membrane expression of CFTR in pancreatic ductal cells via RAC1 inhibition

BACKGROUND AND AIMS: Thiopurine-induced acute pancreatitis (TIP) is one of the most common adverse events among inflammatory bowel disease patients treated with azathioprine (AZA), representing a significant clinical burden. Previous studies focused on immune-mediated processes, however, the exact p...

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Detalles Bibliográficos
Autores principales: Tél, Bálint, Papp, Noémi, Varga, Árpád, Szabó, Viktória, Görög, Marietta, Susánszki, Petra, Crul, Tim, Kis, Aletta, Sendstad, Ingrid H., Bagyánszki, Mária, Bódi, Nikolett, Hegyi, Péter, Maléth, József, Pallagi, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825359/
https://www.ncbi.nlm.nih.gov/pubmed/36609875
http://dx.doi.org/10.1007/s00018-022-04662-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825359/
https://www.ncbi.nlm.nih.gov/pubmed/36609875
http://dx.doi.org/10.1007/s00018-022-04662-y

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