IL-1β neutralization prevents diastolic dysfunction development, but lacks hepatoprotective effect in an aged mouse model of NASH

Interleukin-1β (IL-1β) is a key mediator of non-alcoholic steatohepatitis (NASH), a chronic liver disease, and of systemic inflammation-driven aging. IL-1β contributes to cardio-metabolic decline, and may promote hepatic oncogenic transformation. Therefore, IL-1β is a potential therapeutic target in...

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Detalles Bibliográficos
Autores principales: Kucsera, Dániel, Tóth, Viktória E., Sayour, Nabil V., Kovács, Tamás, Gergely, Tamás G., Ruppert, Mihály, Radovits, Tamás, Fábián, Alexandra, Kovács, Attila, Merkely, Béla, Ferdinandy, Péter, Varga, Zoltán V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825403/
https://www.ncbi.nlm.nih.gov/pubmed/36611037
http://dx.doi.org/10.1038/s41598-022-26896-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825403/
https://www.ncbi.nlm.nih.gov/pubmed/36611037
http://dx.doi.org/10.1038/s41598-022-26896-3

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