Discovery of an L‐like Configuration for 3’‐Fluoro‐5’‐norcarbonucleoside Phosphonates as Potent Anti‐HIV Agents

Recently, we reported the racemic synthesis of 3’‐fluoro‐5’‐norcarbocyclic nucleoside phosphonates bearing adenine as the heterocyclic base. For this study, to evaluate the antiviral activity of each enantiomer, we synthesized both enantiomers, as well as their corresponding bis(POM) prodrugs. Anti‐...

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Detalles Bibliográficos
Autores principales: Geant, Pierre‐Yves, Kaci, Malika, Uttaro, Jean‐Pierre, Périgaud, Christian, Mathé, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825896/
https://www.ncbi.nlm.nih.gov/pubmed/36032023
http://dx.doi.org/10.1002/cmdc.202200377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825896/
https://www.ncbi.nlm.nih.gov/pubmed/36032023
http://dx.doi.org/10.1002/cmdc.202200377

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