Termination of CD40L co‐stimulation promotes human B cell differentiation into antibody‐secreting cells

Human naïve B cells are notoriously difficult to differentiate into antibody‐secreting cells (ASCs) in vitro while maintaining sufficient cell numbers to evaluate the differentiation process. B cells require T follicular helper (T(FH)) cell‐derived signals like CD40L and IL‐21 during germinal center...

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Detalles Bibliográficos
Autores principales: Marsman, Casper, Verstegen, Niels JM, Streutker, Marij, Jorritsma, Tineke, Boon, Louis, ten Brinke, Anja, van Ham, S. Marieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Immunomodulation and immune therapies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825913/
https://www.ncbi.nlm.nih.gov/pubmed/36073009
http://dx.doi.org/10.1002/eji.202249972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825913/
https://www.ncbi.nlm.nih.gov/pubmed/36073009
http://dx.doi.org/10.1002/eji.202249972

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