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The Nϵ‐Rule for Serine, but Not Cysteine Catalytic Triads
Catalytic triads, composed of a serine or cysteine nucleophile, a histidine, and a third triad residue (typically Asp/Glu/Asn), are common in enzyme active sites and catalyze a wide variety of chemical reactions. Two types of triads can be distinguished: We refer to them as Nδ‐ or Nϵ‐configured, dep...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825947/ https://www.ncbi.nlm.nih.gov/pubmed/35983934 http://dx.doi.org/10.1002/anie.202206945 |