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The dynamic interplay of PIP(2) and ATP in the regulation of the K(ATP) channel
ABSTRACT: ATP‐sensitive potassium (K(ATP)) channels couple the intracellular ATP concentration to insulin secretion. K(ATP) channel activity is inhibited by ATP binding to the Kir6.2 tetramer and activated by phosphatidylinositol 4,5‐bisphosphate (PIP(2)). Here, we use molecular dynamics simulation,...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825998/ https://www.ncbi.nlm.nih.gov/pubmed/36047384 http://dx.doi.org/10.1113/JP283345 |