Exploiting Coordination Effects for the Regioselective Zincation of Diazines Using TMPZnX⋅LiX (X=Cl, Br)

A new method for regioselective zincations of challenging N‐heterocyclic substrates such as pyrimidines and pyridazine was reported using bimetallic bases TMPZnX⋅LiX (TMP=2,2,6,6‐tetramethylpiperidyl; X=Cl, Br). Reactions occurred under mild conditions (25–70 °C, using 1.75 equivalents of base witho...

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Detalles Bibliográficos
Autores principales: Kremsmair, Alexander, Sunagatullina, Alisa S., Bole, Leonie J., Mastropierro, Pasquale, Graßl, Simon, Wilke, Henrik R., Godineau, Edouard, Hevia, Eva, Knochel, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826189/
https://www.ncbi.nlm.nih.gov/pubmed/35943036
http://dx.doi.org/10.1002/anie.202210491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826189/
https://www.ncbi.nlm.nih.gov/pubmed/35943036
http://dx.doi.org/10.1002/anie.202210491

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