Mechanism‐Based Design of the First GlnA4‐Specific Inhibitors

γ‐Glutamylamine synthetases are an important class of enzymes that play a key role in glutamate‐based metabolism. Methionine sulfoximine (MSO) is a well‐established inhibitor for the archetypal glutamine synthetase (GS) but inhibitors for most GS‐like enzymes are unknown. Assuming a conserved cataly...

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Detalles Bibliográficos
Autores principales: Purder, Patrick L., Meyners, Christian, Krysenko, Sergii, Funk, Jonathan, Wohlleben, Wolfgang, Hausch, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826267/
https://www.ncbi.nlm.nih.gov/pubmed/35976722
http://dx.doi.org/10.1002/cbic.202200312