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Protein kinase C‐mediated phosphorylation of transient receptor potential melastatin type 2 Thr738 counteracts the effect of cytosolic Ca(2+) and elevates the temperature threshold

ABSTRACT: The transient receptor potential melastatin type 2 (TRPM2) channel is a non‐selective cation channel that has high Ca(2+) permeability. TRPM2 is sensitive to warm temperatures and is expressed in cells and tissues that are maintained at core body temperature. TRPM2 activity is also regulat...

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Detalles Bibliográficos
Autores principales: Kashio, Makiko, Masubuchi, Satoru, Tominaga, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826287/
https://www.ncbi.nlm.nih.gov/pubmed/36042566
http://dx.doi.org/10.1113/JP283350