Enantioselective Total Synthesis of (−)‐Limaspermidine and (−)‐Kopsinine by a Nitroaryl Transfer Cascade Strategy

We report an intramolecular conjugate addition/Truce‐Smiles/E1cb cascade of 2‐nitrobenzenesulfonamide‐functionalized cyclohexenones as a new entry to the core scaffold of monoterpene indole alkaloids. The method was applied to the asymmetric total synthesis of (−)‐limaspermidine, (−)‐kopsinilam, and...

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Detalles Bibliográficos
Autores principales: Horst, Brendan, Verdoorn, Daniël S., Hennig, Sven, van der Heijden, Gydo, Ruijter, Eelco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826323/
https://www.ncbi.nlm.nih.gov/pubmed/36004723
http://dx.doi.org/10.1002/anie.202210592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826323/
https://www.ncbi.nlm.nih.gov/pubmed/36004723
http://dx.doi.org/10.1002/anie.202210592

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