Extending the Structure‐Activity Relationship of Disorazole C(1): Exchanging the Oxazole Ring by Thiazole and Influence of Chiral Centers within the Disorazole Core on Cytotoxicity

The synthesis of novel disorazole C1 analogues is described and their biological activity as cytotoxic compounds is reported. Based on our convergent entry to the disorazole core we present a flexible and robust strategy to construct a variety of interesting new analogues. In particular, two regions...

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Detalles Bibliográficos
Autores principales: Lizzadro, Luca, Spieß, Oliver, Collisi, Wera, Stadler, Marc, Schinzer, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826379/
https://www.ncbi.nlm.nih.gov/pubmed/35998215
http://dx.doi.org/10.1002/cbic.202200458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826379/
https://www.ncbi.nlm.nih.gov/pubmed/35998215
http://dx.doi.org/10.1002/cbic.202200458

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