Native Mass Spectrometry‐Guided Screening Identifies Hit Fragments for HOP‐HSP90 PPI Inhibition

Contemporary medicinal chemistry considers fragment‐based drug discovery (FBDD) and inhibition of protein‐protein interactions (PPI) as important means of expanding the volume of druggable chemical space. However, the ability to robustly identify valid fragments and PPI inhibitors is an enormous cha...

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Detalles Bibliográficos
Autores principales: Vaaltyn, Michaelone C., Mateos‐Jimenez, Maria, Müller, Ronel, Mackay, C. Logan, Edkins, Adrienne L., Clarke, David J., Veale, Clinton G. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826382/
https://www.ncbi.nlm.nih.gov/pubmed/36017658
http://dx.doi.org/10.1002/cbic.202200322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826382/
https://www.ncbi.nlm.nih.gov/pubmed/36017658
http://dx.doi.org/10.1002/cbic.202200322

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