Scaling Catalytic Contributions of Small Self‐Cleaving Ribozymes

Nucleolytic ribozymes utilize general acid‐base catalysis to perform phosphodiester cleavage. In most ribozyme classes, a conserved active site guanosine is positioned to act as general base, thereby activating the 2′‐OH group to attack the scissile phosphate (γ‐catalysis). Here, we present an atomi...

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Detalles Bibliográficos
Autores principales: Egger, Michaela, Bereiter, Raphael, Mair, Stefan, Micura, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826390/
https://www.ncbi.nlm.nih.gov/pubmed/35982640
http://dx.doi.org/10.1002/anie.202207590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826390/
https://www.ncbi.nlm.nih.gov/pubmed/35982640
http://dx.doi.org/10.1002/anie.202207590

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