Two Tags in One Probe: Combining Fluorescence‐ and Biotin‐based Detection of the Trypanosomal Cysteine Protease Rhodesain

Rhodesain is the major cysteine protease of the protozoan parasite Trypanosoma brucei and a therapeutic target for sleeping sickness, a fatal neglected tropical disease. We designed, synthesized and characterized a bimodal activity‐based probe that binds to and inactivates rhodesain. This probe exhi...

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Detalles Bibliográficos
Autores principales: Lemke, Carina, Jílková, Adéla, Ferber, Dominic, Braune, Annett, On, Anja, Johe, Patrick, Zíková, Alena, Schirmeister, Tanja, Mareš, Michael, Horn, Martin, Gütschow, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826439/
https://www.ncbi.nlm.nih.gov/pubmed/35852812
http://dx.doi.org/10.1002/chem.202201636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826439/
https://www.ncbi.nlm.nih.gov/pubmed/35852812
http://dx.doi.org/10.1002/chem.202201636

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