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Photochromic Fentanyl Derivatives for Controlled μ‐Opioid Receptor Activation

Photoswitchable ligands as biological tools provide an opportunity to explore the kinetics and dynamics of the clinically relevant μ‐opioid receptor. These ligands can potentially activate or deactivate the receptor when desired by using light. Spatial and temporal control of biological activity all...

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Autores principales: Lahmy, Ranit, Hübner, Harald, Schmidt, Maximilian F., Lachmann, Daniel, Gmeiner, Peter, König, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826449/
https://www.ncbi.nlm.nih.gov/pubmed/35899620
http://dx.doi.org/10.1002/chem.202201515
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author Lahmy, Ranit
Hübner, Harald
Schmidt, Maximilian F.
Lachmann, Daniel
Gmeiner, Peter
König, Burkhard
author_facet Lahmy, Ranit
Hübner, Harald
Schmidt, Maximilian F.
Lachmann, Daniel
Gmeiner, Peter
König, Burkhard
author_sort Lahmy, Ranit
collection PubMed
description Photoswitchable ligands as biological tools provide an opportunity to explore the kinetics and dynamics of the clinically relevant μ‐opioid receptor. These ligands can potentially activate or deactivate the receptor when desired by using light. Spatial and temporal control of biological activity allows for application in a diverse range of biological investigations. Photoswitchable ligands have been developed in this work, modelled on the known agonist fentanyl, with the aim of expanding the current “toolbox” of fentanyl photoswitchable ligands. In doing so, ligands have been developed that change geometry (isomerize) upon exposure to light, with varying photophysical and biochemical properties. This variation in properties could be valuable in further studying the functional significance of the μ‐opioid receptor.
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spelling pubmed-98264492023-01-09 Photochromic Fentanyl Derivatives for Controlled μ‐Opioid Receptor Activation Lahmy, Ranit Hübner, Harald Schmidt, Maximilian F. Lachmann, Daniel Gmeiner, Peter König, Burkhard Chemistry Research Articles Photoswitchable ligands as biological tools provide an opportunity to explore the kinetics and dynamics of the clinically relevant μ‐opioid receptor. These ligands can potentially activate or deactivate the receptor when desired by using light. Spatial and temporal control of biological activity allows for application in a diverse range of biological investigations. Photoswitchable ligands have been developed in this work, modelled on the known agonist fentanyl, with the aim of expanding the current “toolbox” of fentanyl photoswitchable ligands. In doing so, ligands have been developed that change geometry (isomerize) upon exposure to light, with varying photophysical and biochemical properties. This variation in properties could be valuable in further studying the functional significance of the μ‐opioid receptor. John Wiley and Sons Inc. 2022-09-12 2022-11-11 /pmc/articles/PMC9826449/ /pubmed/35899620 http://dx.doi.org/10.1002/chem.202201515 Text en © 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Lahmy, Ranit
Hübner, Harald
Schmidt, Maximilian F.
Lachmann, Daniel
Gmeiner, Peter
König, Burkhard
Photochromic Fentanyl Derivatives for Controlled μ‐Opioid Receptor Activation
title Photochromic Fentanyl Derivatives for Controlled μ‐Opioid Receptor Activation
title_full Photochromic Fentanyl Derivatives for Controlled μ‐Opioid Receptor Activation
title_fullStr Photochromic Fentanyl Derivatives for Controlled μ‐Opioid Receptor Activation
title_full_unstemmed Photochromic Fentanyl Derivatives for Controlled μ‐Opioid Receptor Activation
title_short Photochromic Fentanyl Derivatives for Controlled μ‐Opioid Receptor Activation
title_sort photochromic fentanyl derivatives for controlled μ‐opioid receptor activation
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826449/
https://www.ncbi.nlm.nih.gov/pubmed/35899620
http://dx.doi.org/10.1002/chem.202201515
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