Diterpene Biosynthesis from Geranylgeranyl Diphosphate Analogues with Changed Reactivities Expands Skeletal Diversity

Two analogues of the diterpene precursor geranylgeranyl diphosphate with shifted double bonds, named iso‐GGPP I and iso‐GGPP II, were enzymatically converted with twelve diterpene synthases from bacteria, fungi and protists. The changed reactivity in the substrate analogues resulted in the formation...

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Detalles Bibliográficos
Autores principales: Li, Heng, Dickschat, Jeroen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826473/
https://www.ncbi.nlm.nih.gov/pubmed/36066489
http://dx.doi.org/10.1002/anie.202211054
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author Li, Heng
Dickschat, Jeroen S.
author_facet Li, Heng
Dickschat, Jeroen S.
author_sort Li, Heng
collection PubMed
description Two analogues of the diterpene precursor geranylgeranyl diphosphate with shifted double bonds, named iso‐GGPP I and iso‐GGPP II, were enzymatically converted with twelve diterpene synthases from bacteria, fungi and protists. The changed reactivity in the substrate analogues resulted in the formation of 28 new diterpenes, many of which exhibit novel skeletons.
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spelling pubmed-98264732023-01-09 Diterpene Biosynthesis from Geranylgeranyl Diphosphate Analogues with Changed Reactivities Expands Skeletal Diversity Li, Heng Dickschat, Jeroen S. Angew Chem Int Ed Engl Research Articles Two analogues of the diterpene precursor geranylgeranyl diphosphate with shifted double bonds, named iso‐GGPP I and iso‐GGPP II, were enzymatically converted with twelve diterpene synthases from bacteria, fungi and protists. The changed reactivity in the substrate analogues resulted in the formation of 28 new diterpenes, many of which exhibit novel skeletons. John Wiley and Sons Inc. 2022-09-21 2022-10-24 /pmc/articles/PMC9826473/ /pubmed/36066489 http://dx.doi.org/10.1002/anie.202211054 Text en © 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Li, Heng
Dickschat, Jeroen S.
Diterpene Biosynthesis from Geranylgeranyl Diphosphate Analogues with Changed Reactivities Expands Skeletal Diversity
title Diterpene Biosynthesis from Geranylgeranyl Diphosphate Analogues with Changed Reactivities Expands Skeletal Diversity
title_full Diterpene Biosynthesis from Geranylgeranyl Diphosphate Analogues with Changed Reactivities Expands Skeletal Diversity
title_fullStr Diterpene Biosynthesis from Geranylgeranyl Diphosphate Analogues with Changed Reactivities Expands Skeletal Diversity
title_full_unstemmed Diterpene Biosynthesis from Geranylgeranyl Diphosphate Analogues with Changed Reactivities Expands Skeletal Diversity
title_short Diterpene Biosynthesis from Geranylgeranyl Diphosphate Analogues with Changed Reactivities Expands Skeletal Diversity
title_sort diterpene biosynthesis from geranylgeranyl diphosphate analogues with changed reactivities expands skeletal diversity
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826473/
https://www.ncbi.nlm.nih.gov/pubmed/36066489
http://dx.doi.org/10.1002/anie.202211054
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AT dickschatjeroens diterpenebiosynthesisfromgeranylgeranyldiphosphateanalogueswithchangedreactivitiesexpandsskeletaldiversity

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