Manipulation of mRNA translation elongation influences the fragmentation of a biotherapeutic Fc‐fusion protein produced in CHO cells

Mammalian cells, particularly Chinese hamster ovary cells, are the dominant system for the production of protein‐based biotherapeutics, however, product degradation, particularly of Fc‐fusion proteins, is sometimes observed that impacts the quality of the protein generated. Here, we identify the sit...

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Detalles Bibliográficos
Autores principales: Knight, Tanya J., Povey, Jane F., Vito, Davide, Mohindra, Atul, Jaques, Colin M., Smales, C. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826484/
https://www.ncbi.nlm.nih.gov/pubmed/36082414
http://dx.doi.org/10.1002/bit.28230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826484/
https://www.ncbi.nlm.nih.gov/pubmed/36082414
http://dx.doi.org/10.1002/bit.28230

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