Inhibition of acetyl-CoA carboxylase impaired tubulin palmitoylation and induced spindle abnormalities

Tubulin s-palmitoylation involves the thioesterification of a cysteine residue in tubulin with palmitate. The palmitate moiety is produced by the fatty acid synthesis pathway, which is rate-limited by acetyl-CoA carboxylase (ACC). While it is known that ACC is phosphorylated at serine 79 (pSer(79))...

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Detalles Bibliográficos
Autores principales: Fang, Chieh-Ting, Kuo, Hsiao-Hui, Amartuvshin, Oyundari, Hsu, Hwei-Jan, Liu, Sih-Long, Yao, Jhong-Syuan, Yih, Ling-Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826786/
https://www.ncbi.nlm.nih.gov/pubmed/36617578
http://dx.doi.org/10.1038/s41420-023-01301-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826786/
https://www.ncbi.nlm.nih.gov/pubmed/36617578
http://dx.doi.org/10.1038/s41420-023-01301-8

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