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Inhibition of acetyl-CoA carboxylase impaired tubulin palmitoylation and induced spindle abnormalities
Tubulin s-palmitoylation involves the thioesterification of a cysteine residue in tubulin with palmitate. The palmitate moiety is produced by the fatty acid synthesis pathway, which is rate-limited by acetyl-CoA carboxylase (ACC). While it is known that ACC is phosphorylated at serine 79 (pSer(79))...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826786/ https://www.ncbi.nlm.nih.gov/pubmed/36617578 http://dx.doi.org/10.1038/s41420-023-01301-8 |