Phosphorylation-dependent interactions of myosin-binding protein C and troponin coordinate the myofilament response to protein kinase A

PKA-mediated phosphorylation of sarcomeric proteins enhances heart muscle performance in response to β-adrenergic stimulation and is associated with accelerated relaxation and increased cardiac output for a given preload. At the cellular level, the latter translates to a greater dependence of Ca(2+)...

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Detalles Bibliográficos
Autores principales: Sevrieva, Ivanka R., Ponnam, Saraswathi, Yan, Ziqian, Irving, Malcolm, Kampourakis, Thomas, Sun, Yin-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826837/
https://www.ncbi.nlm.nih.gov/pubmed/36470422
http://dx.doi.org/10.1016/j.jbc.2022.102767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826837/
https://www.ncbi.nlm.nih.gov/pubmed/36470422
http://dx.doi.org/10.1016/j.jbc.2022.102767

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