Impact of process stress on protein stability in highly-loaded solid protein/PEG formulations from small-scale melt extrusion

As protein-based therapeutics often exhibit a limited stability in liquid formulations, there is a growing interest in the development of solid protein formulations due to improved protein stability in the solid state. We used small-scale (<3 g) ram and twin-screw extrusion for the solid stabiliz...

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Detalles Bibliográficos
Autores principales: Dauer, Katharina, Werner, Christian, Lindenblatt, Dirk, Wagner, Karl Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826855/
https://www.ncbi.nlm.nih.gov/pubmed/36632069
http://dx.doi.org/10.1016/j.ijpx.2022.100154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826855/
https://www.ncbi.nlm.nih.gov/pubmed/36632069
http://dx.doi.org/10.1016/j.ijpx.2022.100154

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