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Impact of process stress on protein stability in highly-loaded solid protein/PEG formulations from small-scale melt extrusion
As protein-based therapeutics often exhibit a limited stability in liquid formulations, there is a growing interest in the development of solid protein formulations due to improved protein stability in the solid state. We used small-scale (<3 g) ram and twin-screw extrusion for the solid stabiliz...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826855/ https://www.ncbi.nlm.nih.gov/pubmed/36632069 http://dx.doi.org/10.1016/j.ijpx.2022.100154 |