Inducing T cell dysfunction by chronic stimulation of CAR-engineered T cells targeting cancer cells in suspension cultures

Several pre-clinical models reveal that chronic chimeric antigen receptor (CAR) stimulation drives a dysfunctional state that mimics in vivo failure. In this protocol, we describe steps to induce T cell dysfunction by persistent and long-term stimulation of CAR-engineered T cells using antigen-expre...

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Detalles Bibliográficos
Autores principales: Selli, Mehmet Emrah, Landmann, Jack H., Arveseth, Corvin, Singh, Nathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826863/
https://www.ncbi.nlm.nih.gov/pubmed/36607811
http://dx.doi.org/10.1016/j.xpro.2022.101954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9826863/
https://www.ncbi.nlm.nih.gov/pubmed/36607811
http://dx.doi.org/10.1016/j.xpro.2022.101954

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