Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway

Wee1-like protein kinase (WEE1) restrains activities of cyclin-dependent kinases (CDKs) in S and G2 phase. Inhibition of WEE1 evokes drastic increase in CDK activity, which perturbs replication dynamics and compromises cell cycle checkpoints. Notably, WEE1 inhibitors such as adavosertib are tested i...

Descripción completa

Detalles Bibliográficos
Autores principales: Petrosius, Valdemaras, Benada, Jan, Nielsen, Olaf, Schoof, Erwin M., Sørensen, Claus Storgaard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827073/
https://www.ncbi.nlm.nih.gov/pubmed/36632060
http://dx.doi.org/10.1016/j.isci.2022.105806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827073/
https://www.ncbi.nlm.nih.gov/pubmed/36632060
http://dx.doi.org/10.1016/j.isci.2022.105806

Ejemplares similares