Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance

Mutations in IDH genes occur frequently in acute myeloid leukemia (AML) and other human cancers to generate the oncometabolite R-2HG. Allosteric inhibition of mutant IDH suppresses R-2HG production in a subset of patients with AML; however, acquired resistance emerges as a new challenge, and the und...

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Detalles Bibliográficos
Autores principales: Lyu, Junhua, Liu, Yuxuan, Gong, Lihu, Chen, Mingyi, Madanat, Yazan F., Zhang, Yuannyu, Cai, Feng, Gu, Zhimin, Cao, Hui, Kaphle, Pranita, Kim, Yoon Jung, Kalkan, Fatma N., Stephens, Helen, Dickerson, Kathryn E., Ni, Min, Chen, Weina, Patel, Prapti, Mims, Alice S., Borate, Uma, Burd, Amy, Cai, Sheng F., Yin, C. Cameron, You, M. James, Chung, Stephen S., Collins, Robert H., DeBerardinis, Ralph J., Liu, Xin, Xu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827114/
https://www.ncbi.nlm.nih.gov/pubmed/36222845
http://dx.doi.org/10.1158/2159-8290.CD-21-1661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827114/
https://www.ncbi.nlm.nih.gov/pubmed/36222845
http://dx.doi.org/10.1158/2159-8290.CD-21-1661

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