Unveiling the inhibitory mechanism of aureusidin targeting xanthine oxidase by multi-spectroscopic methods and molecular simulations

Xanthine oxidase (XO) is a key target for gout treatment. Great efforts have been made towards the discovery and development of new XO inhibitors. Aureusidin (AUR), a natural compound, emerges as the second reported XO inhibitor with an aurone skeleton with an IC(50) value of 7.617 ± 0.401 μM in vit...

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Detalles Bibliográficos
Autores principales: He, Pei, Xu, Haiqi, Yang, Can, Yu, Dehong, Liu, Yi, Du, Jiana, Li, Yanfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827282/
https://www.ncbi.nlm.nih.gov/pubmed/36688063
http://dx.doi.org/10.1039/d2ra06997k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827282/
https://www.ncbi.nlm.nih.gov/pubmed/36688063
http://dx.doi.org/10.1039/d2ra06997k

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