Disruption of CISH promotes the antitumor activity of human T cells and decreases PD-1 expression levels

Tumor cells and the immunosuppressive tumor microenvironment suppress the antitumor activity of T cells through immune checkpoints, including the PD-L1/PD-1 axis. Cytokine-inducible SH2-containing protein (CISH), a member of the suppressor of cytokine signaling (SOCS) family, inhibits JAK-STAT and T...

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Detalles Bibliográficos
Autores principales: Lv, Jiang, Qin, Le, Zhao, Ruocong, Wu, Di, Wu, Zhiping, Zheng, Diwei, Li, Siyu, Luo, Mintao, Wu, Qiting, Long, Youguo, Tang, Zhaoyang, Tang, Yan-Lai, Luo, Xuequn, Yao, Yao, Yang, Li-Hua, Li, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827364/
https://www.ncbi.nlm.nih.gov/pubmed/36654786
http://dx.doi.org/10.1016/j.omto.2022.12.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827364/
https://www.ncbi.nlm.nih.gov/pubmed/36654786
http://dx.doi.org/10.1016/j.omto.2022.12.003

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