Cargando…

Disruption of CISH promotes the antitumor activity of human T cells and decreases PD-1 expression levels

Tumor cells and the immunosuppressive tumor microenvironment suppress the antitumor activity of T cells through immune checkpoints, including the PD-L1/PD-1 axis. Cytokine-inducible SH2-containing protein (CISH), a member of the suppressor of cytokine signaling (SOCS) family, inhibits JAK-STAT and T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lv, Jiang, Qin, Le, Zhao, Ruocong, Wu, Di, Wu, Zhiping, Zheng, Diwei, Li, Siyu, Luo, Mintao, Wu, Qiting, Long, Youguo, Tang, Zhaoyang, Tang, Yan-Lai, Luo, Xuequn, Yao, Yao, Yang, Li-Hua, Li, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827364/ https://www.ncbi.nlm.nih.gov/pubmed/36654786 http://dx.doi.org/10.1016/j.omto.2022.12.003

Ejemplares similares

PSCA is a target of chimeric antigen receptor T cells in gastric cancer
por: Wu, Di, et al.
Publicado: (2020)

Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis
por: Qin, Le, et al.
Publicado: (2022)

Human Hyaluronidase PH20 Potentiates the Antitumor Activities of Mesothelin-Specific CAR-T Cells Against Gastric Cancer
por: Zhao, Ruocong, et al.
Publicado: (2021)

Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer
por: Lv, Jiang, et al.
Publicado: (2019)

The Chemokine Receptor CCR8 Is a Target of Chimeric Antigen T Cells for Treating T Cell Malignancies
por: Zheng, Diwei, et al.
Publicado: (2022)

DAP10 integration in CAR-T cells enhances the killing of heterogeneous tumors by harnessing endogenous NKG2D
por: Li, Shanglin, et al.
Publicado: (2022)

Chimeric antigen receptor T cells targeting PD-L1 suppress tumor growth
por: Qin, Le, et al.
Publicado: (2020)

Chimeric CTLA4-CD28-CD3z T Cells Potentiate Antitumor Activity Against CD80/CD86–Positive B Cell Malignancies
por: Lin, Shouheng, et al.
Publicado: (2021)

Identification of mutations in porcine STAT5A that contributes to the transcription of CISH
por: Yao, Diwen, et al.
Publicado: (2023)

DNAX-activating protein 10 co-stimulation enhances the anti-tumor efficacy of chimeric antigen receptor T cells
por: Zhao, Ruocong, et al.
Publicado: (2018)

Genetic Contribution of CISH Promoter Polymorphisms to Susceptibility to Tuberculosis in Chinese Children
por: Sun, Lin, et al.
Publicado: (2014)

Incorporation of functional elements enhances the antitumor capacity of CAR T cells
por: Qin, Le, et al.
Publicado: (2017)

Classic Intrafascial Supracervical Hysterectomy (CISH): 10-Year Experience
por: Morrison, John E., et al.
Publicado: (2006)

Polymorphisms in CISH Gene Are Associated with Persistent Hepatitis B Virus Infection in Han Chinese Population
por: Hu, Zhangyong, et al.
Publicado: (2014)

Regulation of DC development and DC-mediated T-cell immunity via CISH
por: Miah, Mohammad Alam, et al.
Publicado: (2013)

Cish attenuates proximal TCR-signaling and CD8+ T cell immunity
por: Palmer, Douglas, et al.
Publicado: (2014)

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling
por: Queval, Christophe J., et al.
Publicado: (2017)

Monosomy 3 by chromogenic in situ hybridization (CISH) in Iranian patients with uveal melanoma
por: Naseripour, Masood, et al.
Publicado: (2015)

CISH constrains the tuft–ILC2 circuit to set epithelial and immune tone
por: Kotas, Maya E., et al.
Publicado: (2021)

Association of genetic polymorphisms of CISH with the risk of pulmonary tuberculosis in Zahedan, Southeast Iran
por: Naderi, Mohammad, et al.
Publicado: (2016)

Integrative Analyses of mRNA Expression Profile Reveal SOCS2 and CISH Play Important Roles in GHR Mutation-Induced Excessive Abdominal Fat Deposition in the Sex-Linked Dwarf Chicken
por: Chen, Genghua, et al.
Publicado: (2021)

Cish actively silences tcr signaling in CD8+ T cells to maintain tumor tolerance
por: Palmer, Douglas, et al.
Publicado: (2015)

Cish actively silences TCR signaling in CD8(+) T cells to maintain tumor tolerance
por: Palmer, Douglas C., et al.
Publicado: (2015)

Epitranscriptomic Approach: To Improve the Efficacy of ICB Therapy by Co-Targeting Intracellular Checkpoint CISH
por: Kumar, Sunil, et al.
Publicado: (2021)

Role of Cytokine-Inducible SH2 Domain-Containing (CISH) Protein in the Regulation of Erythropoiesis
por: Maymand, Saeed, et al.
Publicado: (2023)

KLF5 inhibition potentiates anti-PD1 efficacy by enhancing CD8(+) T-cell-dependent antitumor immunity
por: Wu, Qi, et al.
Publicado: (2023)

MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking
por: Peng, Hsuan-Yu, et al.
Publicado: (2020)

Disrupting the phase separation of KAT8–IRF1 diminishes PD-L1 expression and promotes antitumor immunity
por: Wu, Yuanzhong, et al.
Publicado: (2023)

Alpha7 Nicotinic Acetylcholine Receptor Antagonists Prevent Meningitic Escherichia coli-Induced Blood–Brain Barrier Disruptions by Targeting the CISH/JAK2/STAT5b Axis
por: Gong, Zelong, et al.
Publicado: (2022)

Quantification of PRL/Stat5 signaling with a novel pGL4-CISH reporter
por: Fang, Feng, et al.
Publicado: (2008)

CISH promoter polymorphism effects on T cell cytokine receptor signaling and type 1 diabetes susceptibility
por: Seyfarth, Julia, et al.
Publicado: (2018)

Expression of CISH, an Inhibitor of NK Cell Function, Increases in Association with Ovarian Cancer Development and Progression
por: Acosta, Jasmin C., et al.
Publicado: (2023)

Singular Nuclei Segmentation for Automatic HER2 Quantification Using CISH Whole Slide Images
por: Hossain, Md Shakhawat, et al.
Publicado: (2022)

Cish knockout mice exhibit similar outcomes to malaria infection despite altered hematopoietic responses
por: Lakkavaram, Asha L., et al.
Publicado: (2023)

Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells
por: Qin, Le, et al.
Publicado: (2017)

Agreement between chromogenic in situ hybridisation (CISH) and FISH in the determination of HER2 status in breast cancer
por: Arnould, L, et al.
Publicado: (2003)

Study of C-MYC amplification and expression in Iranian gastric cancer samples using CISH and IHC methods
por: Khaleghian, Malihea, et al.
Publicado: (2015)

Novel Complex of PD-L1 Aptamer and Albumin Enhances Antitumor Efficacy In Vivo
por: An, Yacong, et al.
Publicado: (2022)

Human induced-T-to-natural killer cells have potent anti-tumour activities
por: Jiang, Zhiwu, et al.
Publicado: (2022)

Novel Complex of PD-L1 Aptamer and Holliday Junction Enhances Antitumor Efficacy in Vivo
por: Li, Ting, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ajgogcthmrqvf9poc02s9fmqe0