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Differential phosphorylation of Clr4(SUV39H) by Cdk1 accompanies a histone H3 methylation switch that is essential for gametogenesis

Methylation of histone H3 at lysine 9 (H3K9) is a hallmark of heterochromatin that plays crucial roles in gene silencing, genome stability, and chromosome segregation. In Schizosaccharomyces pombe, Clr4 mediates both di‐ and tri‐methylation of H3K9. Although H3K9 methylation has been intensely studi...

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Detalles Bibliográficos
Autores principales: Kuzdere, Tahsin, Flury, Valentin, Schalch, Thomas, Iesmantavicius, Vytautas, Hess, Daniel, Bühler, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827552/
https://www.ncbi.nlm.nih.gov/pubmed/36408846
http://dx.doi.org/10.15252/embr.202255928