Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins

In neutrophils, caspase-11 cleaves gasdermin D (GSDMD), causing pyroptosis to clear cytosol-invasive bacteria. In contrast, caspase-1 also cleaves GSDMD but seems to not cause pyroptosis. Here, we show that this pyroptosis-resistant caspase-1 activation is specifically programmed by the site of tran...

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Detalles Bibliográficos
Autores principales: Oh, Changhoon, Li, Lupeng, Verma, Ambika, Reuven, Arianna D., Miao, Edward A., Bliska, James B., Aachoui, Youssef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827617/
https://www.ncbi.nlm.nih.gov/pubmed/36417874
http://dx.doi.org/10.1016/j.celrep.2022.111688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827617/
https://www.ncbi.nlm.nih.gov/pubmed/36417874
http://dx.doi.org/10.1016/j.celrep.2022.111688

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