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Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins
In neutrophils, caspase-11 cleaves gasdermin D (GSDMD), causing pyroptosis to clear cytosol-invasive bacteria. In contrast, caspase-1 also cleaves GSDMD but seems to not cause pyroptosis. Here, we show that this pyroptosis-resistant caspase-1 activation is specifically programmed by the site of tran...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827617/ https://www.ncbi.nlm.nih.gov/pubmed/36417874 http://dx.doi.org/10.1016/j.celrep.2022.111688 |