Parthenolide reveals an allosteric mode to inhibit the deISGylation activity of SARS-CoV‑2 papain-like protease: Parthenolide covalently inhibits papain-like protease

The coronavirus papain-like protease (PLpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for viral polypeptide cleavage and the deISGylation of interferon-stimulated gene 15 (ISG15), which enable it to participate in virus replication and host innate immune pathway...

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Detalles Bibliográficos
Autores principales: Zou, Zhihui, Shan, Huizhuang, Sun, Demeng, Xia, Li, Shi, Yulong, Wan, Jiahui, Zhou, Aiwu, Wu, Yunzhao, Xu, Hanzhang, Lei, Hu, Xu, Zhijian, Wu, Yingli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827819/
https://www.ncbi.nlm.nih.gov/pubmed/35866602
http://dx.doi.org/10.3724/abbs.2022092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827819/
https://www.ncbi.nlm.nih.gov/pubmed/35866602
http://dx.doi.org/10.3724/abbs.2022092

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