Cargando…

An Anticancer Rhenium Tricarbonyl Targets Fe−S Cluster Biogenesis in Ovarian Cancer Cells

Target identification remains a critical challenge in inorganic drug discovery to deconvolute potential polypharmacology. Herein, we describe an improved approach to prioritize candidate protein targets based on a combination of dose‐dependent chemoproteomics and treatment effects in living cancer c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Neuditschko, Benjamin, King, A. Paden, Huang, Zhouyang, Janker, Lukas, Bileck, Andrea, Borutzki, Yasmin, Marker, Sierra C., Gerner, Christopher, Wilson, Justin J., Meier‐Menches, Samuel M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827826/ https://www.ncbi.nlm.nih.gov/pubmed/36004624 http://dx.doi.org/10.1002/anie.202209136

Ejemplares similares

Rhenium Tricarbonyl Complexes of Azodicarboxylate Ligands
por: Jordan, Rose, et al.
Publicado: (2022)

A Proteomic Platform Enables to Test for AML Normalization In Vitro
por: Meier-Menches, Samuel M., et al.
Publicado: (2022)

Target-specific mononuclear and binuclear rhenium(i) tricarbonyl complexes as upcoming anticancer drugs
por: Sharma S., Ajay, et al.
Publicado: (2022)

Finger sweat analysis enables short interval metabolic biomonitoring in humans
por: Brunmair, Julia, et al.
Publicado: (2021)

Eicosanoid Content in Fetal Calf Serum Accounts for Reproducibility Challenges in Cell Culture
por: Niederstaetter, Laura, et al.
Publicado: (2021)

Click-to-Chelate: Development of Technetium and Rhenium-Tricarbonyl Labeled Radiopharmaceuticals
por: Kluba, Christiane A., et al.
Publicado: (2013)

Recent Emergence of Rhenium(I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy
por: Liew, Hui Shan, et al.
Publicado: (2020)

μ-Hydroxido-bis[(2,2′-bipyridine)tricarbonylrhenium(I)] perrhenate
por: Ruth, Kai, et al.
Publicado: (2008)

Substitution reactivity and structural variability induced by tryptamine on the biomimetic rhenium tricarbonyl complex
por: Jacobs, Frederick J. F., et al.
Publicado: (2021)

Rhenium(I) Tricarbonyl Complexes of 1,10-Phenanthroline Derivatives with Unexpectedly High Cytotoxicity
por: Enslin, Lucy E., et al.
Publicado: (2023)

fac-Bis(acetonitrile-κN)tricarbonyl(trifluoroacetato-κO)rhenium(I)
por: Kia, Reza, et al.
Publicado: (2008)

Tetra-μ(3)-hydroxido-tetrakis[tricarbonylrhenium(I)] pyridine tetrasolvate
por: Schutte, M., et al.
Publicado: (2012)

Highly Cytotoxic Molybdenocenes with Strong Metabolic Effects Inhibit Tumour Growth in Mice
por: Fuchs, Valentin, et al.
Publicado: (2022)

Synthesis and Characterization of Novel [2 + 1] Tricarbonyl Rhenium Complexes with the Hydrophilic Phosphine Ligands PTA and CAP
por: Roupa, Ioanna, et al.
Publicado: (2022)

Antimicrobial Activity of Rhenium Di- and Tricarbonyl Diimine Complexes: Insights on Membrane-Bound S. aureus Protein Binding
por: Schindler, Kevin, et al.
Publicado: (2022)

Interaction with Ribosomal Proteins Accompanies Stress Induction of the Anticancer Metallodrug BOLD‐100/KP1339 in the Endoplasmic Reticulum
por: Neuditschko, Benjamin, et al.
Publicado: (2021)

Epithelial Cell Line Derived from Endometriotic Lesion Mimics Macrophage Nervous Mechanism of Pain Generation on Proteome and Metabolome Levels
por: Neuditschko, Benjamin, et al.
Publicado: (2021)

Inward Outward Signaling in Ovarian Cancer: Morpho-Phospho-Proteomic Profiling Upon Application of Hypoxia and Shear Stress Characterizes the Adaptive Plasticity of OVCAR-3 and SKOV-3 Cells
por: Bileck, Andrea, et al.
Publicado: (2022)

Aberrant DNA Methylation, Expression, and Occurrence of Transcript Variants of the ABC Transporter ABCA7 in Breast Cancer
por: Zappe, Katja, et al.
Publicado: (2023)

Unexpected Redox Chemistry of P∩N- and As∩N-Rhenium(I) Tricarbonyl Complexes in the Presence of CO(2) Acting as an Acid
por: Ertl, Martin, et al.
Publicado: (2023)

Synthesis, structural characterization and study of antioxidant and anti-PrP(Sc) properties of flavonoids and their rhenium(I)–tricarbonyl complexes
por: Glykofridi, Pigi, et al.
Publicado: (2023)

Metabo-tip: a metabolomics platform for lifestyle monitoring supporting the development of novel strategies in predictive, preventive and personalised medicine
por: Brunmair, Julia, et al.
Publicado: (2021)

[Bis(pyridin-2-ylmethyl)amine-κ(3) N,N′,N′′]tricarbonylrhenium(I) bromide hemihydrate
por: Schutte, Marietjie, et al.
Publicado: (2012)

Photochemistry of P,N-bidentate rhenium(i) tricarbonyl complexes: reactive species generation and potential application for antibacterial photodynamic therapy
por: Acosta, Alison, et al.
Publicado: (2021)

Photocatalytic CO(2) reduction sensitized by a special-pair mimic porphyrin connected with a rhenium(i) tricarbonyl complex
por: Kuramochi, Yusuke, et al.
Publicado: (2022)

Fetal Immunomodulatory Environment Following Cartilage Injury—The Key to CARTILAGE Regeneration?
por: Ribitsch, Iris, et al.
Publicado: (2021)

Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function
por: Del Favero, Giorgia, et al.
Publicado: (2021)

Metabolic phenotyping of tear fluid as a prognostic tool for personalised medicine exemplified by T2DM patients
por: Brunmair, Julia, et al.
Publicado: (2022)

fac-Tricarbonyl(pyridine-κN)(1,1,1-trifluoroacetylacetonato-κ(2) O,O′)rhenium(I)
por: Visser, Hendrik G., et al.
Publicado: (2011)

Photocatalytic CO(2) Reductions Catalyzed by meso‐(1,10‐Phenanthrolin‐2‐yl)‐Porphyrins Having a Rhenium(I) Tricarbonyl Complex
por: Kuramochi, Yusuke, et al.
Publicado: (2020)

Deoxynivalenol induces structural alterations in epidermoid carcinoma cells A431 and impairs the response to biomechanical stimulation
por: Del Favero, Giorgia, et al.
Publicado: (2018)

An Organometallic Gold(I) Bis‐N‐Heterocyclic Carbene Complex with Multimodal Activity in Ovarian Cancer Cells
por: Meier‐Menches, Samuel M., et al.
Publicado: (2020)

Tricarbonylchlorido{N-[2-(diphenylphosphino)benzylidene]benzylamine-κ(2) N,P}rhenium(I) dichloromethane solvate
por: Monkowius, Uwe, et al.
Publicado: (2008)

Crystal structure of fac-tricarbonyl(quinoline-2-carboxylato-κ(2) N,O)(triphenylarsane-κAs)rhenium(I)
por: Triantis, Charalampos, et al.
Publicado: (2016)

Synthesis, Characterization, and Biological Studies of a Piperidinyl Appended Dipicolylamine Ligand and Its Rhenium Tricarbonyl Complex as Potential Therapeutic Agents for Human Breast Cancer
por: Subasinghe, Amali, et al.
Publicado: (2016)

Efficient Direct Nitrosylation of α-Diimine Rhenium Tricarbonyl Complexes to Structurally Nearly Identical Higher Charge Congeners Activable towards Photo-CO Release
por: Nasiri Sovari, Sara, et al.
Publicado: (2021)

Multiomics-empowered Deep Phenotyping of Ulcerative Colitis Identifies Biomarker Signatures Reporting Functional Remission States
por: Janker, Lukas, et al.
Publicado: (2023)

Dichotomous Responses to Chronic Fetal Hypoxia Lead to a Predetermined Aging Phenotype
por: Rudloff, Stefan, et al.
Publicado: (2021)

Proteome Analysis Reveals Distinct Mitochondrial Functions Linked to Interferon Response Patterns in Activated CD4+ and CD8+ T Cells
por: Gerner, Marlene C., et al.
Publicado: (2019)

Crystal structure of fac-tricarbonyl(cyclohexyl isocyanide-κC)(quinoline-2-carboxylato-κ(2) N,O)rhenium(I)
por: Triantis, Charalampos, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ojeaqhvs189qrarpeonrpmdm5u