Selective Biocatalytic N‐Methylation of Unsaturated Heterocycles

Methods for regioselective N‐methylation and ‐alkylation of unsaturated heterocycles with “off the shelf” reagents are highly sought‐after. This reaction could drastically simplify synthesis of privileged bioactive molecules. Here we report engineered and natural methyltransferases for challenging N...

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Detalles Bibliográficos
Autores principales: Ospina, Felipe, Schülke, Kai H., Soler, Jordi, Klein, Alina, Prosenc, Benjamin, Garcia‐Borràs, Marc, Hammer, Stephan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827881/
https://www.ncbi.nlm.nih.gov/pubmed/36202763
http://dx.doi.org/10.1002/anie.202213056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827881/
https://www.ncbi.nlm.nih.gov/pubmed/36202763
http://dx.doi.org/10.1002/anie.202213056

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