Templated Generation of a Bcl‐x(L) Inhibitor by Isomer‐Free SPAAC Based on Azacyclonon‐5‐yne

High‐affinity inhibitors of large protein–protein interactions often have a high molecular weight, which compromises their cell permeability and oral bioavailability. We recently presented isomer‐free, strain‐promoted azide‐alkyne cycloaddition (iSPAAC) as a method by which to generate large, chemic...

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Detalles Bibliográficos
Autores principales: Brauer, Juliane, Mötzing, Marina, Gröst, Corinna, Hoffmann, Ralf, Berg, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827882/
https://www.ncbi.nlm.nih.gov/pubmed/35989238
http://dx.doi.org/10.1002/chem.202202259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827882/
https://www.ncbi.nlm.nih.gov/pubmed/35989238
http://dx.doi.org/10.1002/chem.202202259

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