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Templated Generation of a Bcl‐x(L) Inhibitor by Isomer‐Free SPAAC Based on Azacyclonon‐5‐yne
High‐affinity inhibitors of large protein–protein interactions often have a high molecular weight, which compromises their cell permeability and oral bioavailability. We recently presented isomer‐free, strain‐promoted azide‐alkyne cycloaddition (iSPAAC) as a method by which to generate large, chemic...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827882/ https://www.ncbi.nlm.nih.gov/pubmed/35989238 http://dx.doi.org/10.1002/chem.202202259 |