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From DC18 to MR07: A Metabolically Stable 4,4′‐Oxybisbenzoyl Amide as a Low‐Nanomolar Growth Inhibitor of P. falciparum
To improve the metabolic stability of a 4,4′‐oxybisbenzoyl‐based novel and potent (nanomolar‐range IC(50)) antiplasmodial agent previously described by us, in silico‐guided structure‐activity relationship (SAR) campaigns have been conducted to substitute its peptide decorations with more metabolical...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827966/ https://www.ncbi.nlm.nih.gov/pubmed/36089546 http://dx.doi.org/10.1002/cmdc.202200355 |