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From DC18 to MR07: A Metabolically Stable 4,4′‐Oxybisbenzoyl Amide as a Low‐Nanomolar Growth Inhibitor of P. falciparum

To improve the metabolic stability of a 4,4′‐oxybisbenzoyl‐based novel and potent (nanomolar‐range IC(50)) antiplasmodial agent previously described by us, in silico‐guided structure‐activity relationship (SAR) campaigns have been conducted to substitute its peptide decorations with more metabolical...

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Detalles Bibliográficos
Autores principales: Bassanini, Ivan, Parapini, Silvia, Basilico, Nicoletta, Taramelli, Donatella, Romeo, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827966/
https://www.ncbi.nlm.nih.gov/pubmed/36089546
http://dx.doi.org/10.1002/cmdc.202200355