Cargando…

From DC18 to MR07: A Metabolically Stable 4,4′‐Oxybisbenzoyl Amide as a Low‐Nanomolar Growth Inhibitor of P. falciparum

To improve the metabolic stability of a 4,4′‐oxybisbenzoyl‐based novel and potent (nanomolar‐range IC(50)) antiplasmodial agent previously described by us, in silico‐guided structure‐activity relationship (SAR) campaigns have been conducted to substitute its peptide decorations with more metabolical...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bassanini, Ivan, Parapini, Silvia, Basilico, Nicoletta, Taramelli, Donatella, Romeo, Sergio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827966/ https://www.ncbi.nlm.nih.gov/pubmed/36089546 http://dx.doi.org/10.1002/cmdc.202200355

Ejemplares similares

Design, Synthesis and In Vitro Investigation of Novel Basic Celastrol Carboxamides as Bio-Inspired Leishmanicidal Agents Endowed with Inhibitory Activity against Leishmania Hsp90
por: Bassanini, Ivan, et al.
Publicado: (2021)

The Lipid Moiety of Haemozoin (Malaria Pigment) and P. falciparum Parasitised Red Blood Cells Bind Synthetic and Native Endothelin-1
por: Basilico, Nicoletta, et al.
Publicado: (2010)

Safety of Artemisinin Derivatives in the First Trimester of Pregnancy: A Controversial Story
por: D’Alessandro, Sarah, et al.
Publicado: (2020)

Phagocytosis and activation of bone marrow‐derived macrophages by Plasmodium falciparum gametocytes
por: Corbett, Yolanda, et al.
Publicado: (2021)

A new P. falciparum gametocyte drug screening assay based on pLDH detection
por: D’Alessandro, Sarah, et al.
Publicado: (2012)

In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial
por: Basilico, Nicoletta, et al.
Publicado: (2017)

Synthesis, Molecular Docking and Antiplasmodial Activities of New Tetrahydro-β-Carbolines
por: Jaromin, Anna, et al.
Publicado: (2021)

In Vitro Antiparasitic Activities of Monovalent Ionophore Compounds for Human and Canine Leishmaniases
por: Calvo Alvarez, Estefanía, et al.
Publicado: (2022)

Favorable Preclinical Pharmacological Profile of a Novel Antimalarial Pyrrolizidinylmethyl Derivative of 4-amino-7-chloroquinoline with Potent In Vitro and In Vivo Activities
por: Basilico, Nicoletta, et al.
Publicado: (2023)

Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities
por: Wu, Yuet, et al.
Publicado: (2018)

Leishmania Promastigotes Enhance Neutrophil Recruitment through the Production of CXCL8 by Endothelial Cells
por: D’Alessandro, Sarah, et al.
Publicado: (2021)

In Vitro SARS-CoV-2 Infection of Microvascular Endothelial Cells: Effect on Pro-Inflammatory Cytokine and Chemokine Release
por: Dolci, Maria, et al.
Publicado: (2022)

Interplay between Plasmodium falciparum haemozoin and l-arginine: implication for nitric oxide production
por: Corbett, Yolanda, et al.
Publicado: (2018)

Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity
por: Pozzetti, Luca, et al.
Publicado: (2022)

Antiparasitic Drugs against SARS-CoV-2: A Comprehensive Literature Survey
por: Calvo-Alvarez, Estefanía, et al.
Publicado: (2022)

Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria
por: Dell'Agli, Mario, et al.
Publicado: (2010)

Palmitic Acid Analogs Exhibit Nanomolar Binding Affinity for the HIV-1 CD4 Receptor and Nanomolar Inhibition of gp120-to-CD4 Fusion
por: Paskaleva, Elena E., et al.
Publicado: (2010)

Photoresponsive Amide-Based Derivatives of Azobenzene-4,4′-Dicarboxylic Acid—Experimental and Theoretical Studies
por: Łukasik, Natalia, et al.
Publicado: (2021)

Antimalarial Activity of Tri- and Tetra-Substituted Anilino Pyrazoles
por: Lusardi, Matteo, et al.
Publicado: (2023)

Azacarbazole n-3 and n-6 polyunsaturated fatty acids ethyl esters nanoemulsion with enhanced efficacy against Plasmodium falciparum
por: Jaromin, Anna, et al.
Publicado: (2020)

Determination and Identification of Nicarbazin, Measured as 4,4′-Dinitrocarbanilide (DNC), in Chicken Tissues by Liquid Chromatography With Tandem Mass Spectrometry: Final Action 2013.07
por: Brunelle, Sharon L, et al.
Publicado: (2022)

Hemozoin impairs cell cycle progression and promotes chemokine release in human microvascular endothelial cells
por: Basilico, Nicoletta, et al.
Publicado: (2012)

Antiplasmodial Activity of p-Substituted Benzyl Thiazinoquinone Derivatives and Their Potential against Parasitic Infections
por: Casertano, Marcello, et al.
Publicado: (2020)

Synthesis and Antiplasmodial Activity of Novel Bioinspired Imidazolidinedione Derivatives
por: Jaromin, Anna, et al.
Publicado: (2020)

A refined method for analysis of 4,4′-dicofol and 4,4′-dichlorobenzophenone
por: Yin, Ge, et al.
Publicado: (2017)

In vitro antiplasmodial and cytotoxic properties of some medicinal plants from western Burkina Faso
por: Sanon, Souleymane, et al.
Publicado: (2013)

Minutes IPP meeting on 4 07 94
por: ten Have, I
Publicado: (1994)

Genotoxicological Characterization of (±)cis-4,4′-DMAR and (±)trans-4,4′-DMAR and Their Association
por: Lenzi, Monia, et al.
Publicado: (2022)

PEGylation Potentiates the Effectiveness of an Antagonistic Peptide That Targets the EphB4 Receptor with Nanomolar Affinity
por: Noberini, Roberta, et al.
Publicado: (2011)

Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor
por: Lamberto, Ilaria, et al.
Publicado: (2014)

Sensitization and cross‐reactivity patterns of contact allergy to diisocyanates and corresponding amines: investigation of diphenylmethane‐4,4′‐diisocyanate, diphenylmethane‐4,4′‐diamine, dicyclohexylmethane‐4,4′‐diisocyanate, and dicylohexylmethane‐4,4′‐diamine
por: Hamada, Haneen, et al.
Publicado: (2017)

Disodium 4,4′-oxydibenzoate
por: Yang, Yuan, et al.
Publicado: (2008)

4,4′-Azinodibenzoic acid
por: Yu, Qun-Di, et al.
Publicado: (2009)

Bis(4,4′-bipyridinium) dodecatungstosilicate 4,4′-bipyridine hexahydrate
por: Ma, Feng-Xia, et al.
Publicado: (2008)

4,4′-[4,4′-Sulfonylbis(p-phenyleneoxy)]dibutanoic acid
por: Fu, Chun-Yan, et al.
Publicado: (2011)

Crystal structure of 4,4′-(disulfanediyl)dibutanoic acid–4,4′-bipyridine (1/1)
por: Atria, Ana María, et al.
Publicado: (2014)

P07-10. Natural compounds in bodily fluids which bind DC-SIGN and prevent HIV-1 capture and transfer to CD4 cells
por: Stax, MJ, et al.
Publicado: (2009)

Effects of combined drug treatments on Plasmodium falciparum: In vitro assays with doxycycline, ivermectin and efflux pump inhibitors
por: Nodari, Riccardo, et al.
Publicado: (2020)

Dihydroxy-Substituted Coumarins as Fluorescent Probes for Nanomolar-Level Detection of the 4-Amino-TEMPO Spin Label
por: Żamojć, Krzysztof, et al.
Publicado: (2019)

4-Chlorobenzothioamide
por: Khan, Mahmood-ul-Hassan, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_jo7rrg7fiae7fak8fsqoan51ji