Cargando…

Identification of 2,4‐Dinitro‐Biphenyl‐Based Compounds as MAPEG Inhibitors

We identified 2,4‐dinitro‐biphenyl‐based compounds as new inhibitors of leukotriene C(4) synthase (LTC(4)S) and 5‐lipoxygenase‐activating protein (FLAP), both members of the “Membrane Associated Proteins in Eicosanoid and Glutathione metabolism” (MAPEG) family involved in the biosynthesis of pro‐inf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di Micco, Simone, Terracciano, Stefania, Pierri, Martina, Cantone, Vincenza, Liening, Stefanie, König, Stefanie, Garscha, Ulrike, Hofstetter, Robert Klaus, Koeberle, Andreas, Werz, Oliver, Bruno, Ines, Bifulco, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827972/ https://www.ncbi.nlm.nih.gov/pubmed/36111583 http://dx.doi.org/10.1002/cmdc.202200327

Ejemplares similares

Expression and functional analysis of the propamocarb-related gene CsMAPEG in cucumber
por: Zhang, Fan, et al.
Publicado: (2019)

Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol
por: Noha, Stefan M., et al.
Publicado: (2015)

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase
por: Garscha, Ulrike, et al.
Publicado: (2017)

Bis[2-(2,4-dinitrobenzyl)pyridinium] biphenyl-4,4′-disulfonate trihydrate
por: Smith, Graham, et al.
Publicado: (2010)

Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A(4) Hydrolase
por: Teder, Tarvi, et al.
Publicado: (2023)

N-[1-(Biphenyl-4-yl)ethylidene]-N′-(2,4-dinitrophenyl)hydrazine
por: Kia, Reza, et al.
Publicado: (2009)

1-(2,4-Dinitrophenyl)-3,3-dinitroazetidine
por: Yan, Biao, et al.
Publicado: (2009)

2,4-Dinitrobenzaldehyde hydrazone
por: Zhang, Nan, et al.
Publicado: (2008)

2,4-Dinitro-1-naphthol
por: Raza, Abdul Rauf, et al.
Publicado: (2010)

A second monoclinic polymorph of N-(2,4-dinitrophenyl)-2,4-dinitroaniline
por: Tokutome, Yui, et al.
Publicado: (2013)

2,4-Dinitro-1-phenoxybenzene
por: Du, Zhen-Ting, et al.
Publicado: (2010)

Repositioning of Quinazolinedione-Based Compounds on Soluble Epoxide Hydrolase (sEH) through 3D Structure-Based Pharmacophore Model-Driven Investigation
por: Gazzillo, Erica, et al.
Publicado: (2022)

From Cyanobacteria to Human, MAPEG-Type Glutathione-S-Transferases Operate in Cell Tolerance to Heat, Cold, and Lipid Peroxidation
por: Kammerscheit, Xavier, et al.
Publicado: (2019)

Crystal structure of 4,4′-dinitro-[1,1′-biphenyl]-2-amine
por: Faizi, Md. Serajul Haque, et al.
Publicado: (2017)

Identification of 2-(thiophen-2-yl)acetic Acid-Based Lead Compound for mPGES-1 Inhibition
por: Di Micco, Simone, et al.
Publicado: (2021)

2,4-Dichlorobenzaldehyde 2,4-dinitrophenylhydrazone
por: Bao, Feng-yu
Publicado: (2008)

But-2-enal 2,4-dinitrophenylhydrazone
por: Yin, Zhi-Gang, et al.
Publicado: (2008)

N′-(2,4-Dinitrophenyl)acetohydrazide
por: Zia-ur-Rehman, Muhammad, et al.
Publicado: (2008)

Triethylammonium 2,4-dinitrophenylbarbiturate
por: Kalaivani, Doraisamyraja, et al.
Publicado: (2009)

N′-(2,4-Dinitrophenyl)benzohydrazide
por: Saeed, Aamer, et al.
Publicado: (2012)

A polymorph of 2,4-dinitrophenylhydrazine
por: Amimoto, Kiichi, et al.
Publicado: (2013)

Bis(2,4-dinitrophenyl)sulfane
por: Buvaneswari, M, et al.
Publicado: (2012)

Development of SFC-MS Method for Quantification of Eicosanoids Biosynthesized in Primary Human Blood Cells
por: Schmidt, Louis, et al.
Publicado: (2022)

2-(2,4-Dinitrobenzyl)pyridinium 2-hydroxy-3,5-dinitrobenzoate
por: Smith, Graham, et al.
Publicado: (2010)

2,4-Dinitro-1-naphthyl 4-toluenesulfonate
por: Ramachandran, G., et al.
Publicado: (2008)

3-Pentanone 2,4-dinitrophenylhydrazone
por: Xu, Lu-Feng, et al.
Publicado: (2008)

2-Methoxybenzaldehyde 2,4-dinitrophenylhydrazone
por: Fun, Hoong-Kun, et al.
Publicado: (2009)

Structural Refinement of 2,4-Thiazolidinedione Derivatives as New Anticancer Agents Able to Modulate the BAG3 Protein
por: Ruggiero, Dafne, et al.
Publicado: (2022)

Protective Effect of Casperome(®), an Orally Bioavailable Frankincense Extract, on Lipopolysaccharide- Induced Systemic Inflammation in Mice
por: Loeser, Konstantin, et al.
Publicado: (2018)

Thiophene-2-carbaldehyde 2,4-dinitrophenylhydrazone
por: Yin, Zhi-gang, et al.
Publicado: (2008)

N-(2,4-Dinitrophenyl)dehydroabietylamine
por: Qiu, Fei, et al.
Publicado: (2008)

2-Hydroxyethanaminium 2,4-dinitrophenolate hemihydrate
por: Yan, Yong, et al.
Publicado: (2010)

Triterpene Acids from Frankincense and Semi-Synthetic Derivatives That Inhibit 5-Lipoxygenase and Cathepsin G
por: Koeberle, Andreas, et al.
Publicado: (2018)

1-Cyclopentylidene-2-(2,4-dinitrophenyl)hydrazine
por: Ji, Ning-Ning, et al.
Publicado: (2008)

(E)-1-(2,4-Dinitrophenyl)-2-pentylidenehydrazine
por: Neunfeldt, Patrícia D., et al.
Publicado: (2010)

(E)-2-Furyl methyl ketone 2,4-dinitrophenylhydrazone
por: Shan, Shang, et al.
Publicado: (2008)

N-Cycloheptylidene-N′-(2,4-dinitrophenyl)hydrazine
por: Kia, Reza, et al.
Publicado: (2009)

In Silico, In Vitro and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from Salvia miltiorrhiza as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway
por: Saviano, Anella, et al.
Publicado: (2022)

(2,4-Dinitrophenyl)(1-methyl-1-nitroethyl)diazene
por: Yuan, Chunlan
Publicado: (2008)

Methyl 2,2-bis(2,4-dinitrophenyl)ethanoate
por: Kalaivani, D., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_8dts1usv2161i8dga6onbvj5e7