Molecular Docking Studies, Synthesis and Biological Evaluation of Substituted Pyrimidine‐2,4‐diamines as Inhibitors of Plasmodium falciparum Dihydrofolate Reductase

A series of 5‐[(phenethylamino)methyl]pyrimidine‐2,4‐diamines were assessed in silico as potential inhibitors of Plasmodium falciparum dihydrofolate reductase (PfDHFR), synthesised and tested for inhibitory activity against PfDHFR in vitro. The compounds displayed promising inhibitory activity again...

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Detalles Bibliográficos
Autores principales: Somandi, Khonzisizwe, Seanego, Tswene D., Dlamini (née Molatsane), Tebogo, Maree, Matthew, de Koning, Charles B., Vanichtanankul, Jarunee, Rattanajak, Roonglawan, Saeyang, Thanaya, Yuthavong, Yongyuth, Kamchonwongpaisan, Sumalee, Rousseau, Amanda L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827987/
https://www.ncbi.nlm.nih.gov/pubmed/36193872
http://dx.doi.org/10.1002/cmdc.202200418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827987/
https://www.ncbi.nlm.nih.gov/pubmed/36193872
http://dx.doi.org/10.1002/cmdc.202200418

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