Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development

PTEN is one of the most commonly inactivated tumour suppressor genes in sporadic cancer. Germline heterozygous PTEN gene alterations also underlie PTEN hamartoma tumour syndrome (PHTS), a rare human cancer‐predisposition condition. A key feature of systemic PTEN deregulation is the inability to adeq...

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Detalles Bibliográficos
Autores principales: Tibarewal, Priyanka, Rathbone, Victoria, Constantinou, Georgia, Pearce, Wayne, Adil, Mahreen, Varyova, Zofia, Folkes, Lisa, Hampson, Alix, Classen, Gala Anastasia Electra, Alves, Adriana, Carvalho, Sara, Scudamore, Cheryl L, Vanhaesebroeck, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828006/
https://www.ncbi.nlm.nih.gov/pubmed/36073856
http://dx.doi.org/10.1002/path.6009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828006/
https://www.ncbi.nlm.nih.gov/pubmed/36073856
http://dx.doi.org/10.1002/path.6009

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