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2,1-Benzothiazine – (quinolin/thiophen)yl hydrazone frameworks as new monoamine oxidase inhibitory agents; synthesis, in vitro and in silico investigation

Two series of new 2,1-benzothiazine derivatives have been synthesized by condensation of 4-hydrazono-1-methyl-3,4-dihydro-1H-benzo[c][1,2]thiazine 2,2-dioxide (5) with 2-chloroquinoline-3-carbaldehydes and acetylthiophenes to acquire new heteroaryl ethylidenes 7(a–f) and 9(a–k) in excellent yields....

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Detalles Bibliográficos
Autores principales: Javid, Noman, Jalil, Saquib, Munir, Rubina, Zia-ur-Rehman, Muhammad, Sahar, Amna, Arshad, Sara, Iqbal, Jamshed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828044/
https://www.ncbi.nlm.nih.gov/pubmed/36712607
http://dx.doi.org/10.1039/d2ra07045f