Sactipeptide Engineering by Probing the Substrate Tolerance of a Thioether‐Bond‐Forming Sactisynthase

Sactipeptides are ribosomally synthesized peptides containing a unique sulfur to α‐carbon crosslink. Catalyzed by sactisynthases, this thioether pattern endows sactipeptides with enhanced structural, thermal, and proteolytic stability, which makes them attractive scaffolds for the development of nov...

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Detalles Bibliográficos
Autores principales: Ali, Ataurehman, Happel, Dominic, Habermann, Jan, Schoenfeld, Katrin, Macarrón Palacios, Arturo, Bitsch, Sebastian, Englert, Simon, Schneider, Hendrik, Avrutina, Olga, Fabritz, Sebastian, Kolmar, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828075/
https://www.ncbi.nlm.nih.gov/pubmed/36049110
http://dx.doi.org/10.1002/anie.202210883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828075/
https://www.ncbi.nlm.nih.gov/pubmed/36049110
http://dx.doi.org/10.1002/anie.202210883

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