Loss of tetraspanin‐7 expression reduces pancreatic β‐cell exocytosis Ca(2+) sensitivity but has limited effect on systemic metabolism

BACKGROUND: Tetraspanin‐7 (Tspan7) is an islet autoantigen involved in autoimmune type 1 diabetes and known to regulate β‐cell L‐type Ca(2+) channel activity. However, the role of Tspan7 in pancreatic β‐cell function is not yet fully understood. METHODS: Histological analyses were conducted using im...

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Detalles Bibliográficos
Autores principales: McLaughlin, Kerry, Acreman, Samuel, Nawaz, Sameena, Cutteridge, Joseph, Clark, Anne, Knudsen, Jakob G., Denwood, Geoffrey, Spigelman, Aliya F., Manning Fox, Jocelyn E., Singh, Sumeet Pal, MacDonald, Patrick E., Hastoy, Benoit, Zhang, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
RESEARCH: BASIC SCIENCE SPECIAL ISSUE
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828109/
https://www.ncbi.nlm.nih.gov/pubmed/36264270
http://dx.doi.org/10.1111/dme.14984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828109/
https://www.ncbi.nlm.nih.gov/pubmed/36264270
http://dx.doi.org/10.1111/dme.14984

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