Tunable Toxicity of Bufadienolides is Regulated through a Configuration Inversion Catalyzed by a Short‐Chain Dehydrogenase/Reductase

Bufadienolides are toxic components widely found in amphibious toads that exhibit a wide range of biological activities. Guided by UPLC‐QTOF‐MS analysis, several 3‐epi‐bufadienolides with unique structures were isolated from the bile of the Asiatic toad, Bufo gargarizans. However, the enzymatic mach...

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Detalles Bibliográficos
Autores principales: Ye, Ge, Huang, Weihuan, Chen, Zeping, Zhong, Hao, Zhong, Junhao, Guo, Xiaoxin, Huang, Yuheng, Kandalai, Shruthi, Zhou, Xiaozhuang, Zhang, Nan, Zhou, Yang, Zheng, Qingfei, Tian, Haiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828183/
https://www.ncbi.nlm.nih.gov/pubmed/36125775
http://dx.doi.org/10.1002/cbic.202200473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9828183/
https://www.ncbi.nlm.nih.gov/pubmed/36125775
http://dx.doi.org/10.1002/cbic.202200473

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